Chemical composition and modifying activity of essential oil of Lantana camara L. (wild sage) against Candida strains

Felicidade Caroline Rodrigues, José Weverton Almeida Bezerra, Nadghia Figueiredo Leite, Antonia Eliene Duarte, Adrielle Rodrigues Costa, Kleber Ribeiro Fidelis, Juliana Lima Silva, Aline Augusti Boligon, Maria Ivaneide Rocha, Luiz Marivando Barros, Henrique Douglas Melo Coutinho, Jean Paul Kamdem, Maria Flaviana Bezerra Morais-Braga

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Introduction: Fungal infections, particularly those caused by the genus Candida, are an important public health problem. Lantana camara L. stands out among the medicinal species with abundant biological and pharmacological activity.
Objective: Analyze the phytochemical profile of essential oil of L. camara and evaluate its antioxidant capacity and modifying antifungal potential against various Candida strains.
Methods: Identification of the chemical components present in the essential oil of L. camara was performed by gas chromatography / mass spectrometry (GC/MS). Antioxidant activity was determined by elimination of free DPPH radicals. Antifungal activity of the essential oil of L. camara leaves was evaluated by microdilution against Candida albicans, C. krusei and C. tropicalis.
Results: It was found that the essential oil of L. camara leaves is rich in terpenes, mainly sesquiterpenes, (E)-caryophyllene (25.80 %), germacrene D (17.36 %), γ-elemene (7.62 %) and sabinene (6.61 %). The essential oil displayed very low activity in DPPH radical elimination, while it displayed antimicrobial activity against the study strains (MIC ≥ 1 024 μg/ml), but it significantly modified the effect of fluconazole against Candida kruzei and C. tropicalis.
Conclusions: The essential oil of L. camara was found to be a good modifier of fluconazole, but it does not have any relevant antioxidant activity.

Key words: modifying activity, antioxidant activity, wild sage, Lantana camara.