Cytotoxic action of the stem aqueous extract of the stem of Cereus jamacaru DC. (mandacaru)

Darciella Moura da Silva Darci, Francisco Ronielson de Sousa Carvalho Ronielson, Antônio Gabriel Moura Gabriel, Ana Paula Peron

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Introduction: cereus jamacaru DC. (Cactaceae), with popular name mandacaru, is a plant from the Brazilian semiarid region with medicinal properties against various diseases.
Objective: to evaluate the effect of different concentrations of crude aqueous extracts obtained from C. jamacaru on the cell cycle of meristematic root cells of Allium cepa L.
Methods: the C. jamacaru aqueous extracts were prepared by trituration of pieces from inside the cladodes immersed in distilled water. The concentration considered optimal for the treatment of diseases is 500/2 L. From this concentration were more established other two 500/1.5 and 500/1 L. Each concentration was evaluated at times of 24 and 48 hours exposure. A group of five bulbs of A. cepa was used. The root tips were collected and fixed in acetic acid (3:1) for 24 hours. The slides were prepared by crushing and stained with 2 % acetic orcein. Data analysis was performed using the Chi-square (p < 0.05).
Results: the results showed that the concentrations of 500/1.5 and 500/1 g/L have an antiproliferative effect and induced a statistically significant number of cellular aberrations in the test system cells in question.
Conclusion: under the conditions studied, these two concentrations present as cytotoxic.